abstract：:The supply of deceased donor kidneys is inadequate to meet demand. To expand the pool of potential donors, ABO-incompatible transplants from living donors have been performed. We present the Mayo Clinic experience with such transplants. Enrollment was open to patients when the only available potential living kidney do...

journal_title：Journal of clinical apheresis

authors： Winters JL,Gloor JM,Pineda AA,Stegall MD,Moore SB

更新日期：2004-01-01 00:00:00

abstract：:Thrombotic microangiopathy (TMA) is a recognized complication of malignant hypertension (HTN). Such patients have blood pressures > or = 200/140 mmHg but the condition is defined by the presence of papilledema and is frequently complicated by acute renal failure. Here we report two patients with severe HTN (systolic >...

journal_title：Journal of clinical apheresis

authors： Egan JA,Bandarenko N,Hay SN,Paradowski L,Goldberg R,Nickeleit V,Brecher ME

更新日期：2004-01-01 00:00:00

abstract：:When harvesting peripheral progenitor cells (PPC) in children, the special situation of their circulatory system has to be taken into account. Therefore, extracorporeal blood volume and product volume should be small to avoid side effects. Nine children (age 2-14 years, weight 12.8-58.5 kg) with malignancies underwent...

journal_title：Journal of clinical apheresis

authors： Moog R,Basu O,Kremens B

更新日期：2003-01-01 00:00:00

abstract：:One of the most serious problems in applying leukapheresis to human infants is the large extracorporeal blood volume (ECV), resulting in substantial loss of platelets and red blood cells (RBCs). In this study, we developed a safe and effective modified procedure to collect peripheral blood stem cells (PBSCs) from rhes...

journal_title：Journal of clinical apheresis

authors： Ageyama N,Kimikawa M,Eguchi K,Ono F,Shibata H,Yoshikawa Y,Terao K

更新日期：2003-01-01 00:00:00

abstract：:Because the administration of hematopoietic growth factors and the use of stem cell support often fails to alleviate the neutropenic phase induced by cytotoxic drugs, several investigators have attempted to expand ex vivo hematopoietic progenitors for clinical use. These attempts have clearly shown that the cultured c...

journal_title：Journal of clinical apheresis

authors： Estrov Z,Huh YO,Ginsberg CF,Harris D,Van Q,Mirza NQ,Talpaz M,Korbling M

更新日期：2002-01-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been shown to be clinically effective in the treatment of many T cell-mediated conditions. ECP's mechanism of action includes the induction of apoptosis and the release of pro-inflammatory cytokines. Recently, we have observed early lymphoid apoptosis, detectable immediately post...

journal_title：Journal of clinical apheresis

authors： Bladon J,Taylor P

更新日期：2002-01-01 00:00:00

abstract：:Focal segmental glomerulosclerosis (FSGS) recurs in 30% of renal allograft transplants with graft loss in half of the cases. A humoral factor may be implicated. We report on the use of therapeutic plasma exchange (TPE) in 11 patients with recurrent FSGS post transplantation. Medical records from 1989-2000 were reviewe...

journal_title：Journal of clinical apheresis

authors： Shariatmadar S,Noto TA

更新日期：2002-01-01 00:00:00

abstract：:Plasma replacement for thrombotic thrombocytopenic purpura (TTP) is accomplished with various plasma products. This study sought to determine the incidence of allergic reactions with FFP or CPP as replacement in therapeutic plasma exchange (TPE). Forty-one TTP patients were identified retrospectively who received TPE ...

journal_title：Journal of clinical apheresis

authors： Reutter JC,Sanders KF,Brecher ME,Jones HG,Bandarenko N

更新日期：2001-01-01 00:00:00

abstract：:For therapeutic plasma exchange (TPE), continuous flow separators are known to be efficient as exemplified by Fresenius AS104 and COBE Spectra. The AS104 uses an interface monitoring system in the centrifuge during TPE, whereas Spectra uses computer algorithms to establish the plasma-cell interface. To determine the p...

journal_title：Journal of clinical apheresis

authors： Burgstaler EA,Pineda AA

更新日期：2001-01-01 00:00:00

abstract：:Since the introduction of hematopoietic growth factors, the collection of mobilized stem cells via leukapheresis has widely replaced the harvest of bone marrow in both autologous and allogeneic transplantation settings. We investigated the frequency and the extent of anticoagulant-induced electrolyte changes and the c...

journal_title：Journal of clinical apheresis

authors： Schlenke P,Frohn C,Steinhardt MM,Kirchner H,Klüter H

更新日期：2000-01-01 00:00:00

abstract：:Acute thrombotic thrombocytopenic purpura (TTP) occurred in three patients following abdominal surgeries. One patient underwent extensive lysis for intestinal adhesions with bowel resection, another cholecystectomy for acute cholecystitis, and the third right colectomy and partial intestinal resection for colon cancer...

journal_title：Journal of clinical apheresis

authors： Chang JC,El-Tarabily M,Gupta S

更新日期：2000-01-01 00:00:00

abstract：:Until recently, the collection of peripheral blood progenitor cells (PBPC) has been semi-automated by using the COBE Spectra, with the operator manually maintaining the position of the white cells being collected. The COBE Spectra Version 6.0 apheresis device offers the user an automated program for the collection of ...

journal_title：Journal of clinical apheresis

authors： Wilke R,Brettell M,Prince HM,Wolf M,McKenna R,Serpell E,Molloy M,Stevens H,Quinn M,Gates P,Chapple P

更新日期：1999-01-01 00:00:00

abstract：:Idiopathic inflammatory demyelinating diseases (IIDDs) of the central nervous system, of which multiple sclerosis is the prototype, represent a family of monophasic, recurrent or progressive diseases with overlapping clinical and pathological manifestations. While most patients recover spontaneously or following a bri...

journal_title：Journal of clinical apheresis

authors： Weinshenker BG

更新日期：1999-01-01 00:00:00

abstract：:Thrombopoietin (TPO) serum levels in 14 patients (9 male and 5 female, mean age 36 years, range 16 to 55 years) with breast cancer (n = 5), testicular cancer (n = 7), or lymphoma (n = 2), undergoing high dose chemotherapy with peripheral blood stem cell (PBSC) transplantation, were evaluated at the first day of the mo...

journal_title：Journal of clinical apheresis

authors： Bojko P,Nowak N,Moritz T,Flasshove M,Harstrick A,Seeber S

更新日期：1999-01-01 00:00:00

abstract：:This study was undertaken to evaluate the relationship between the time to recovery of peripheral blood counts and CD34+ cells in the peripheral blood (PB) and apheresis collections of patients undergoing intensive chemotherapy followed by rhG-CSF. Twenty-three patients with a median age of 42 years (range 17-64) with...

journal_title：Journal of clinical apheresis

authors： Williams O,Demirer T,Lilleby K,Buckner CD,Bensinger WI

更新日期：1998-01-01 00:00:00

abstract：:Complement-derived anaphylatoxin may be one of the causes of vascular injury and an indicator of activity in systemic lupus erythematosus (SLE). The present study examines the effectiveness of dextran sulfate (DS) column immunoadsorption treatment to remove anaphylatoxins (C3a, C4a, and C5a) from the blood of patients...

journal_title：Journal of clinical apheresis

authors： Matsuki Y,Suzuki K,Kawakami M,Ishizuka T,Hidaka T,Nakamura H

更新日期：1998-01-01 00:00:00

abstract：:Prestorage leukocyte reduction of platelet concentrates may reduce adverse effects of transfusion while affording better quality control. Platelets and leukocytes may undergo activation during storage, which could affect the performance of leukocyte reduction filters. The purpose of this study was to evaluate the effi...

journal_title：Journal of clinical apheresis

authors： Jin YS,Mintz PD

更新日期：1997-01-01 00:00:00

abstract：:The blood flow property is one of the factors determining blood perfusion and oxygen supply. The viscosity of the blood is primarily related to the hematocrit, but also to the amount of fibrinogen and other macromolecules present in the blood. Patients with ischemic heart disease have shown a rapid and safe improvemen...

journal_title：Journal of clinical apheresis

authors： Fadul JE,Linde T,Sandhagen B,Wikström B,Danielson BG

更新日期：1997-01-01 00:00:00

abstract：:Thrombopoietin (c-Mpl ligand) is the hematopoietic growth factor that is responsible for regulating the production of platelets from bone marrow megakaryocytes. This approximately 90 kd protein has recently been isolated and is comprised of an erythropoietin domain that is approximately 50% homologous to erythropoieti...

journal_title：Journal of clinical apheresis

authors： Kuter DJ

更新日期：1996-01-01 00:00:00

abstract：:The purpose of this study is to determine whether immunoadsorption treatment using a dextran sulfate (DS) column can remove high-avidity anti-double-stranded DNA (anti-dsDNA) antibody from the blood of patients with systemic lupus erythematosus (SLE). Before and after each immunoadsorption therapy routine, titers of t...

journal_title：Journal of clinical apheresis

authors： Matsuki Y,Suzuki K,Kawakami M,Ishizuka T,Kawaguchi Y,Hidaka T,Nakamura H

更新日期：1996-01-01 00:00:00

abstract：:A "snapshot" survey of physician coverage for evaluation and supervision of therapeutic apheresis procedures shows significant variation in current clinical practice between 39 blood center-and 41 non-blood center-based programs. Whereas 56% of blood center-based programs usually require physician's "in person" evalua...

journal_title：Journal of clinical apheresis

authors： Woll JE

更新日期：1995-01-01 00:00:00

abstract：:In-line leukocyte reduction filters (LRF) are available for use with an automated plateletpheresis (PPH) system. Initially, 62% of PPH units produced with such a filter (LRF6, N = 29) had postfiltration (POF) white blood cell (WBC) counts < 5 x 10(6), with a mean POF WBC of 42 x 10(6). In an attempt to decrease POF WB...

journal_title：Journal of clinical apheresis

authors： Drew MJ,Hodges J

更新日期：1995-01-01 00:00:00

abstract：:Modest success has been achieved with the use of high-dose cytotoxic therapy and bone marrow transplantation in solid tumors. Patient outcome can potentially be improved with further intensification of the therapy. The rapid hematologic recovery achieved with mobilized peripheral blood progenitor cells (PBPC) may redu...

journal_title：Journal of clinical apheresis

authors： Ghalie R,Richman CM,Bender JG,McLeod BC,Lee W,Czyzewski A,Manson S,Cobleigh MA,Reed S,Pierre R

更新日期：1994-01-01 00:00:00

abstract：:Staphylococcal protein A efficiently binds immunoglobulins and circulating immune complexes (CIC) and provides an effective medium to remove immunoglobulins and CICs from plasma while sparing albumin and most coagulation proteins. Although it activates the complement system its clinical use abrogates the need for plas...

journal_title：Journal of clinical apheresis

authors： Howe RB,Christie DJ

更新日期：1994-01-01 00:00:00

abstract：:We have reviewed our initial experience with a program of concurrent collection of plasma (CCP) during plateletpheresis, which was instituted to increase the number of units of fresh frozen plasma produced by our hospital-based donor service. Sixty percent of eligible donors (1,006 of 1,682) participated in CCP, and 2...

journal_title：Journal of clinical apheresis

authors： Burger SR,Thomas BT,Grishaber JE

更新日期：1994-01-01 00:00:00

abstract：:The cell separator MCS-3P is an apheresis system offering the flexibility to collect standardized red blood cells, plasma, and/or platelets from one donor. Two different programs were used for the red cell apheresis--RBCP (collection of one unit of red cells and two units of plasma) and RBCPS (one unit of red cells an...

journal_title：Journal of clinical apheresis

authors： Matthes G,Tofote U,Krause KP,Pawlow I,Kucera W,Lerche D

更新日期：1994-01-01 00:00:00

abstract：:To compare donor demographics and motivations for donation, we surveyed 159 consecutive whole blood donors (WD) and 146 consecutive plateletpheresis donors. All donors had donation experiences of at least 2 gallons (i.e., 16 previous donations). Evaluation of answers to fixed-response and open-ended questions revealed...

journal_title：Journal of clinical apheresis

authors： Julius CJ,Sytsma SR

更新日期：1993-01-01 00:00:00

abstract：:Treatment by low density lipoprotein (LDL) apheresis using dextran sulfate columns (DSC) leads to hemostasis alterations with prolonged activated partial thromboplastin time (APTT) of more than 120 seconds. In order to explain this hypocoagulability, we studied hemostasis parameters both in patients and in the extraco...

journal_title：Journal of clinical apheresis

authors： Lorenzini JL,Dutrillaux F,Mousson C,Lassale B,Maynadié M,Rifle G

更新日期：1993-01-01 00:00:00

abstract：:Peripheral blood stem cells (PBSC) reinfusion appears to hasten hematologic reconstitution following myeloablative therapy. While procurement of PBSC adds apheresis procedures, rapid engraftment could decrease the demand for platelet transfusions. To determine the impact of PBSC collection on workload in our apheresis...

journal_title：Journal of clinical apheresis

authors： Ghalie R,McLeod B,Richman C,Valentino L,Manson S,Netols C,Kaizer H

更新日期：1992-01-01 00:00:00

abstract：:Either bone marrow or peripheral blood may be harvested to provide hematopoietic stem cells (HSC) for autologous transplantation. Both, however, comprise heterogeneous cell populations. The HSC necessary for successful engraftment constitute a very small fraction of the cells harvested. After collection, the harvested...

journal_title：Journal of clinical apheresis

authors： Rowley SD

更新日期：1992-01-01 00:00:00

abstract：:The recent introduction of low-density lipoprotein (LDL)/very low-density lipoprotein (VLDL) selective-removal systems offers an alternative to plasma exchange (PE). For the last 10 years, we have treated a male homozygous hypercholesterolemia type IIA patient with PE using 5% normal serum albumin (NSA) replacement, P...

journal_title：Journal of clinical apheresis

authors： Burgstaler EA,Pineda AA

更新日期：1992-01-01 00:00:00

abstract：:Inadvertent hypothermia due to massive infusion of stored blood can be prevented by pretransfusion warming. One approach is the heating of individual packs by means of electromagnetic conduction, which is a method safely used over the last 25 years. The prototype instrument, which has now been re-engineered, can effec...

journal_title：Journal of clinical apheresis

authors： Harrison GG,Bird AR,Jacobs P,Coghlan P,Byrne MJ,Ozinsky J,Besseling JL

更新日期：1992-01-01 00:00:00

abstract：:Folinic acid (FA) has been reported to expand the pool of peripheral blood stem cells (PBSC) after chemotherapy. We evaluated the efficacy of FA for harvesting PBSC following cytotoxic chemotherapy in 4 patients with acute leukemia. After achieving a complete remission (CR), 3 courses of chemotherapy for a consolidati...

journal_title：Journal of clinical apheresis

authors： Teshima T,Harada M,Takamatsu Y,Inaba S,Kondo S,Akashi K,Okamura T,Niho Y

更新日期：1992-01-01 00:00:00

abstract：:The influence of 6 weeks of cyclosporin A (CYA), followed by a further 6 weeks of this agent in combination with plasma exchange (PE), was defined on panel reactivity and titre of preformed cytotoxic antibodies in stable patients on haemodialysis awaiting renal transplantation. Nine individuals with antibodies to 30% ...

journal_title：Journal of clinical apheresis

authors： Swanepoel CR,Cassidy MJ,May M,Oudshoorn M,du Toit E,Wood L,Jacobs P

更新日期：1991-01-01 00:00:00

abstract：:"Leukocyte-depleted" platelet concentrates (LD-SDPC) were prepared by cotton-wool and by polyester filtration of "leukocyte-poor" PC collected by the elutriation technique. The storage characteristics of LD-SDPC were comparable to those of the filtered pools of multiple donor platelet concentrates (LD-MDPC). However, ...

journal_title：Journal of clinical apheresis

authors： Elias MK,de Wolf JT,Blom N,Rijskamp L,Halie RM,Smit Sibinga CT

更新日期：1991-01-01 00:00:00

abstract：:Many apheresis units lack the resources to acquire customized computer software for record keeping. We have adapted a commercially available "spreadsheet" program (Lotus 1-2-3) to aid in quality control activities for plateletpheresis. Data are entered in a grid pattern wherein each donation occupies one row and succe...

journal_title：Journal of clinical apheresis

authors： McLeod BC,Viernes A,Reed S,Sassetti RJ

更新日期：1990-01-01 00:00:00

abstract：:The removal of specific antibody in experimental animals has been reported to result in a subsequent increase in antibody to levels equal to (rebound) or exceeding those existing prior to removal (overshoot). Anecdotal reports suggest that rebound antibody synthesis after plasmapheresis may occur in humans with autoim...

journal_title：Journal of clinical apheresis

authors： Nasca TJ,Muder RR,Thomas DB,Schrecker JC,Ruben FL

更新日期：1990-01-01 00:00:00

abstract：:A patient with a hyper-IgE syndrome was treated with 60 plasmaphereses over a period of 2 years in conjunction with cytotoxic immunosuppressive drug therapy. During this time her severe dermatitis of 8 years' duration became almost completely inactive, and her circulating IgE level was reduced by 73%. An elevated pret...

journal_title：Journal of clinical apheresis

authors： Dau PC

更新日期：1988-01-01 00:00:00

abstract：:Graphite furnace atomic absorption spectroscopy was used to demonstrate a fivefold increase in the median plasma aluminium levels of four patients undergoing therapeutic plasmapheresis. This plasma aluminium loading resulted from contamination of albumin incorporated in the replacement fluids and took place during its...

journal_title：Journal of clinical apheresis

authors： Monteagudo F,Wood L,Jacobs P,Folb P,Cassidy M

更新日期：1987-01-01 00:00:00

abstract：:An improved method for intermittent-flow erythrocytapheresis in patients with sickle cell disease is reported. The method, a modification of the standard red cell exchange procedure for the Haemonetics 30S unit, dilutes with physiologic saline the patient's blood as it flows from the draw line and before it reaches th...

journal_title：Journal of clinical apheresis

authors： Castro O,Finke-Castro H,Coats D

更新日期：1986-01-01 00:00:00